diff --git a/freqtrade/freqtradebot.py b/freqtrade/freqtradebot.py
index 5505005ff..c150d1aa9 100644
--- a/freqtrade/freqtradebot.py
+++ b/freqtrade/freqtradebot.py
@@ -689,8 +689,13 @@ class FreqtradeBot:
             self._notify_sell(trade, "stoploss")
             return True
 
+        if trade.open_order_id:
+            # Trade has an open Buy or Sell order, Stoploss-handling can't happen in this case
+            # as the Amount on the exchange is tied up in another trade.
+            return False
+
         # If buy order is fulfilled but there is no stoploss, we add a stoploss on exchange
-        if (not trade.open_order_id and not stoploss_order):
+        if (not stoploss_order):
 
             stoploss = self.edge.stoploss(pair=trade.pair) if self.edge else self.strategy.stoploss