diff --git a/freqtrade/plugins/pairlist/RemotePairList.py b/freqtrade/plugins/pairlist/RemotePairList.py
index 764c16f1a..d077330e0 100644
--- a/freqtrade/plugins/pairlist/RemotePairList.py
+++ b/freqtrade/plugins/pairlist/RemotePairList.py
@@ -143,6 +143,9 @@ class RemotePairList(IPairList):
 
         if self._init_done:
             pairlist = self._pair_cache.get('pairlist')
+            if pairlist == [None]:
+                # Valid but empty pairlist.
+                return []
         else:
             pairlist = []
 
@@ -181,7 +184,11 @@ class RemotePairList(IPairList):
         pairlist = self._whitelist_for_active_markets(pairlist)
         pairlist = pairlist[:self._number_pairs]
 
-        self._pair_cache['pairlist'] = pairlist.copy()
+        if pairlist:
+            self._pair_cache['pairlist'] = pairlist.copy()
+        else:
+            # If pairlist is empty, set a dummy value to avoid fetching again
+            self._pair_cache['pairlist'] = [None]
 
         if time_elapsed != 0.0:
             self.log_once(f'Pairlist Fetched in {time_elapsed} seconds.', logger.info)